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KMID : 1134820230520050437
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Journal of the Korean Society of Food Science and Nutrition
2023 Volume.52 No. 5 p.437 ~ p.449
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Effect of Artemisia littoricola Extracts on Melanogenesis in Murine Melanoma Cells
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Yang Ji-Ho
Lee Hyun-Jung
Xianrong Zhou
Jeon Seong-Eun
Choi Mi-Na
Oh Jung-Hwan
Fatih Karadeniz
Seo Young-Wan
Kong Chang-Suk
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Abstract
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Skin color is determined by melanin distributed in the skin, hair, eye, heart, and brain. Melanin protects the skin against ultraviolet and scavenges the cellular reactive oxygen species. However, the abnormal accumulation of melanin induces hyperpigmentation diseases such as melisma, freckles, etc. Recent studies have focused on discovering plant-origin whitening agents against hyperpigmentation with fewer side effects and higher biocompatibility. Salt marsh plants have unique functional secondary metabolites that are not present in land plants due to their special habitat conditions comprising mixed inorganic salts and organic substances. Artemisia littoricola is a halophyte classified as belonging to the division Magnoliophyta, class Magnoliopsida, order Asterales, family Asteraceae, and genus Artemisia. It is expected that by cultivating and collecting this plant, large amounts of raw material can be procured for the cosmetic industry. This study examines the crude extract and solvent-fractionated extracts of A. littoricola (H2O, n-butanol, 85% aq. MeOH, and n-hexane) and evaluates the inhibition of melanogenesis in B16F10 murine melanoma cells. The crude extract and solvent fractions of A. littoricola inhibited the oxidation of tyrosine and L-DOPA in a concentration-dependent manner, indicating an inhibitory effect on melanin production. All extracts also inhibited the expression of proteins responsible for melanin synthesis, namely TRP-1 and TRP-2. Results of the current study reveal the anti-melanogenic properties of A. littoricola and indicate the potential application as a natural source of cosmeceutical agents with skin-whitening effects.
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KEYWORD
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Artemisia littoricola, B16F10, melanogenesis, salt marsh plant, whitening
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